Evaluation of MRX PT DOAC as a new screening method for detecting interferences in thrombophilia analyses.

Background: Direct oral anticoagulants (DOACs) can interfere with coagulation analyses, causing erroneous results such as false-positive lupus anticoagulant and false-normal antithrombin, threatening patient safety when overlooked. A test using a prothrombin time quotient method to detect DOAC presence in plasma samples is now commercially available, the MRX PT DOAC, with the result expressed as Clot Time Ratio (CTR).

Objectives: Evaluate the ability of MRX PT DOAC to identify interfering apixaban or rivaroxaban concentrations, identify non-interfering or interfering patient samples, and detect whether a patient is on DOAC treatment.

Prospective validation study of a combined urine and plasma test for predicting high-grade prostate cancer in biopsy naïve men.

Objective: Early and accurate diagnosis of prostate cancer (PC) is crucial for effective treatment. Diagnosing  clinically insignificant cancers can lead to overdiagnosis and overtreatment, highlighting the importance of accurately selecting patients for further evaluation based on improved risk prediction tools. Novel biomarkers offer promise for enhancing this diagnostic process.

Socioeconomic status moderates the effect of physical education on overweight and obesity in children: a quasi-experimental trial.

Unlabelled: This study aimed to estimate the effects of an intensive school-based physical education intervention on the risk of developing overweight or obesity in primary school students when accounting for the moderating role of socioeconomic status. This quasi-experimental trial included data from primary school students participating in an intensive physical education program comprising 4.5 h of weekly physical activity compared to 1.

A modified iChip for cultivation of bacteria in arid environments.

Antimicrobial resistance is an ever-increasing problem for human health, and with only a few novel antimicrobials discovered in recent decades, an extraordinary effort is needed to circumvent this crisis. A promising source of new microbial-derived antimicrobial compounds resides in the large fraction of microbes that are not readily cultured by standard cultivation. It has previously been shown that nests of the social spider contain a diverse bacterial community, where only a small fraction of the microbes could be recovered by standard cultivation.