Triphenyl-Modified Mixed-Mode Stationary Phases With and Without Embedded Ion-Exchange Sites for High-Performance Liquid Chromatography.

The present work reports on the preparation, characterization, and evaluation of a set of novel triphenyl-modified silica-based stationary phases without and with embedded ion-exchange sites for mixed-mode liquid chromatography. The three synthesized triphenyl phases differed in additionally incorporated ion-exchange sites. In one embodiment, allyltriphenylsilane was bonded to thiol-modified silica by thiol-ene click reaction, leading to particles with no ion-exchange sites.

Increase in prevalence and costs of cirrhosis in the Netherlands: a nationwide hospital diagnosis data analysis.

Introduction: Due to the rising incidence of patients with cirrhosis and its accompanied extensive management, there is an increasing burden of cirrhosis patients on healthcare resources and costs. However, exact data on Dutch cirrhosis epidemiology and associated costs are lacking.

Aims And Methods: We aimed to determine the year-prevalence of adults (aged ≥18 years) with cirrhosis registered as active patients in Dutch hospitals (2017-2021) using the Dutch hospital claims database.

Initial evaluation of 4-palmitoyloxy butyrate in whole blood as potential biomarker after γ-hydroxybutyric acid intake.

The problem of finding a suitable biomarker to widen the detection window of γ-hydroxybutyric acid (GHB) intake remains a challenge in forensic toxicology. Based on previously published results, the present study deals with the evaluation of a fatty acid ester of GHB (4-palmitoyloxy butyrate (GHB-Pal)) in whole blood as a potential biomarker to extend the detection window of GHB use e.g.

Clipped Topography-Guided Treatments: A Different Approach to Custom Corrections.

Purpose: To present a new approach to customized treatments that inherently saves tissue by design, especially for pathological corneas.

Methods: From the elevation of the anterior cornea and the refractive error of the eye, the target cornea can be calculated and the difference between actual and target cornea corresponds to the tissue to be removed. In this approach, it is further possible to preset the ablation depth at one (Model 1) or two (Models 2 and 3) particular locations.

Understanding NCLEX-RN Repeat Writers' Learning Needs: A Pilot Developmental Design Research Study.

Background: Graduates who fail the National Council Licensing Examination for Registered Nurses (NCLEX-RN) require evidence-informed educational support.

Method: This educational development study tested an online program created by a nurse educator and researcher for Canadian-educated nursing students ( = 19) who were taking the NCLEX-RN for the second time. Data collected were biweekly virtual meetings with detailed field notes, program completion data, and self-reported NCLEX-RN results.