Publications by authors named "M R Husa"
C/EBP homologous protein drives pro-catabolic responses in chondrocytes.
Arthritis Res Ther
November 2014
Introduction: Excess C/EBP homologous protein (CHOP) expression is one feature of the unfolded protein response (UPR) to endoplasmic reticulum (ER) stress. Here, we focused on CHOP expression and function in chondrocytes.
Methods: We studied human knee osteoarthritis (OA) cartilage, bovine chondrocytes cultured in alginate and subjected to sub-lethal biomechanical injury, and knee chondrocytes of human autopsy donors.
Introduction: AMP-activated protein kinase (AMPK) maintains cultured chondrocyte matrix homeostasis in response to inflammatory cytokines. AMPK activity is decreased in human knee osteoarthritis (OA) chondrocytes. Liver kinase B1 (LKB1) is one of the upstream activators of AMPK.
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- Liposomes are effective for delivering drugs through the skin due to their ability to modify how drugs are distributed in the body.
- A study used lysine derivatives (Lys-5 and Lys-7) to enhance the structure of liposomes containing fluconazole and analyzed their impact on drug permeability.
- Results showed that these oligopeptides caused a structural change in the liposomes, reducing their size by 10% to 40% and slowing down the skin absorption of fluconazole.
Background: Occluded coronary arteries should be opened urgently in patients who have acute myocardial infarction and ST-elevation in ECG. When transport times are long, thrombolytic treatment is a good alternative to primary percutaneous coronary intervention (PCI). The purpose of this study was to assess choice of treatment strategy in cases where time after start of symptoms and transport time are decisive for the outcome.
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