TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling.

Chromosomal instability (CIN) is common in solid tumours and fuels evolutionary adaptation and poor prognosis by increasing intratumour heterogeneity. Systematic characterization of driver events in the TRACERx non-small-cell lung cancer (NSCLC) cohort identified that genetic alterations in six genes, including FAT1, result in homologous recombination (HR) repair deficiencies and CIN. Using orthogonal genetic and experimental approaches, we demonstrate that FAT1 alterations are positively selected before genome doubling and associated with HR deficiency.

Sex and gender as predictors for allograft and patient-relevant outcomes after kidney transplantation.

Background: Sex, as a biological construct, and gender, defined as the cultural attitudes and behaviours attributed by society, may be associated with allograft loss, death, cancer, and rejection. Other factors, such as recipient age and donor sex, may modify the association between sex/gender and post-transplant outcomes.

Objectives: We sought to evaluate the prognostic effects of recipient sex and, separately, gender as independent predictors of graft loss, death, cancer, and allograft rejection following kidney or simultaneous pancreas-kidney (SPK) transplantation.

Development and Implementation of a 3-Week Whole-Food Plant-Based Vegan Diet Intervention for College Students.

Objective: To describe the research methods used for the Diet and Health Study, a pilot-feasibility study to assess the impact of a whole-food plant-based vegan diet on college students' physical and mental health.

Design: This 3-week theory-based pilot-feasibility study will employ a stratified, randomized control design (2 intervention groups and 1 comparison group) with measurement of primary and secondary outcomes at baseline and postintervention and end-of-study focus groups.

Setting: Southeastern public state university.

Successful Collaboration: A Tale of a Tertiary Care Hospital and Its Designated Organ Procurement Organization.

The death of a child is a tragedy of astronomical proportions. Pediatric trauma patients often have injuries so extensive that there is no hope of recovery. Though the tragedy can never be undone, organ donation can save lives and create a legacy for the donor and their loved ones.