Childhood Pb-induced cognitive dysfunction: structural equation modeling of hot and cold executive functions.

Background: Childhood lead [Pb] exposure has been consistently linked to neurotoxic effects related to the prefrontal cortex, a critical mediating structure involved in decision-making, planning, problem-solving, and specific aspects of short-term memory, i.e., the components of executive functions [EFs].

Dual function of mannosyltransferase, MNT5, in biofilm community protection from antifungal therapy and the host.

Unlabelled: Screen of mutants from a mannosyltransferase family identified the importance of for biofilm drug resistance and neutrophil evasion. Biochemical analysis of the mutant matrix and cell wall identified alterations in the mannan structures. Resistance and matrix for were restored with delivery of wild-type matrix via extracellular vesicles.

Understanding Telomere Biology in Hematopoietic Cell Transplantation: A Dynamical Systems Perspective.

Background: T cell proliferation and repertoire reconstitution is a hallmark of successful hematopoietic cell transplantation (HCT). This process may be modeled as a dynamical system and in such a system, precise telomere length (TL) measurement may reflect the proliferative capacity of donor T cells. TL for different chromosomes span a few orders of magnitude, and different T cell clones will display variable TL; these differences across the population are not represented when examining average TL.

Health-Related Quality of Life in Long COVID: Mapping the Condition-Specific C19-YRSm Measure Onto the EQ-5D-5L.

Background: Long COVID (LC) is a clinical syndrome with persistent, fluctuating symptoms subsequent to COVID-19 infection. LC has significant detrimental effects on health-related quality of life (HRQoL), activities of daily living (ADL), and work productivity. Condition-specific patient-reported outcome measures (PROMs), such as the modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) do not provide the health utility data required for cost-utility analyses of LC interventions.

A generative model for inorganic materials design.

The design of functional materials with desired properties is essential in driving technological advances in areas such as energy storage, catalysis and carbon capture. Generative models accelerate materials design by directly generating new materials given desired property constraints, but current methods have a low success rate in proposing stable crystals or can satisfy only a limited set of property constraints. Here we present MatterGen, a model that generates stable, diverse inorganic materials across the periodic table and can further be fine-tuned to steer the generation towards a broad range of property constraints.