Publications by authors named "M R Hedayati-Moghaddam"
Article Synopsis
- The study focused on occult hepatitis B infection (OBI) in blood donors who tested negative for the hepatitis B surface antigen (HBsAg) in Mashhad, Iran.
- Researchers tested serum samples from 540 HBsAg-negative donors for antibodies against HBV core antigen (anti-HBc) and found that 5.4% were anti-HBc positive, but no HBV DNA was detected in any of the samples.
- The study suggests that blood donations in Iran should be routinely screened for anti-HBc and anti-HBs antibodies, rather than for HBV DNA.
Article Synopsis
- The study assessed the humoral immune response to COVID-19 vaccines in individuals infected with HTLV-1 in northeastern Iran over nearly a year.
- It involved 86 HTLV-1 positive individuals and 90 matched seronegative controls, revealing that those with HTLV-1 had significantly lower antibody responses to the vaccines, even after 2 or 3 doses.
- The findings suggest that people living with HTLV-1 demonstrate a reduced immune response to COVID-19 vaccination, particularly among those displaying specific symptoms of the disease.
One third of the world population has a history of exposure to the hepatitis B virus (HBV), and two billion people are infected with latent tuberculosis (TB). Occult hepatitis B infection (OBI) is defined as the presence of replicative-competent HBV DNA in the liver with detectable or undetectable HBV DNA in the serum of individuals testing negative for the HBV surface antigen (HBsAg). Screening with HBV DNA could identify OBI and significantly reduce carriers and complications of chronic hepatitis B (CHB).
View Article and Find Full Text PDFBackground: The epidemiology and prevalence of the Human T-cell leukemia virus type-1 (HTLV-1) infection represent a recommended priority by global health agencies. An in-depth revision to update the status of this infection in countries including those of the Eastern Mediterranean Regional Office (EMRO) of the World Health Organization is hence required.
Methods: Ninety-seven studies evaluating the HTLV-1 infection in low- and high-risk populations in EMRO countries were retrieved from the international electronic databases and were used to assess the epidemiological status of the infection in these countries.
Background: The presence of hepatitis C virus (HCV) RNA in liver tissue or peripheral blood mononuclear cells with no identified virus genome in the serum has been reported worldwide among patients with either normal or elevated serum liver enzymes. The characterization of occult HCV infection (OCI) epidemiology in the Middle East and Eastern Mediterranean (M and E) countries, a region with the highest incidence and prevalence rates of HCV infection in the world, would be effective for more appropriate control of the infection.
Aim: To estimate the pooled prevalence of OCI in M and E countries using a systematic review and meta-analysis.