Publications by authors named "M R Harkness"
Background: Around one in three pregnant women undergoes induction of labour in the United Kingdom, usually preceded by in-hospital cervical ripening to soften and open the cervix.
Objectives: This study set out to determine whether cervical ripening at home is within an acceptable safety margin of cervical ripening in hospital, is effective, acceptable and cost-effective from both National Health Service and service user perspectives.
Design: The CHOICE study comprised a prospective multicentre observational cohort study using routinely collected data (CHOICE cohort), a process evaluation comprising a survey and nested case studies (qCHOICE) and a cost-effectiveness analysis.
[F]SynVesT-1 is a PET radiopharmaceutical that binds to the synaptic vesicle protein 2A (SV2A) and serves as a biomarker of synaptic density with widespread clinical research applications in psychiatry and neurodegeneration. The initial goal of this study was to concurrently conduct PET imaging studies with [F]SynVesT-1 at our laboratories. However, the data in the first two human PET studies had anomalous biodistribution despite the injected product meeting all specifications during the prerelease quality control protocols.
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- Induction of labour is when doctors help start a pregnancy, usually because continuing the pregnancy might be risky for the baby.
- In the UK, doctors suggest a process called cervical ripening as the first step, and some places are letting women do this at home, even though there's not much proof that it works well.
- A study talked to midwives and doctors to understand how induction care works, and they found that managing this process can be really complicated and has a big impact on their workloads.
Article Synopsis
- - The study examined women's experiences and perspectives on the induction of labor (IOL) process, focusing on cervical ripening (CR) at home versus in a hospital setting.
- - Findings indicated that women often lack sufficient information to make informed choices about IOL, leading to anxiety and a feeling of reduced options for their birth experience.
- - Positive interactions with maternity staff significantly impacted women's overall experience, while issues like staffing shortages and delays in care raised concerns about safety and the quality of care received.
Ibrutinib is a first-generation Bruton's tyrosine kinase (BTK) inhibitor that has shown efficacy in autoimmune diseases and has consequently been developed as a positron emission tomography (PET) radiotracer. Herein, we report the automated radiosynthesis of [C]ibrutinib through C-carbonylation of the acrylamide functional group, by reaction of the secondary amine precursor with [C]CO, iodoethylene, and palladium-NiXantphos. [C]Ibrutinib was reliably formulated in radiochemical yields of 5.
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