Simultaneous determination of arsenite and arsenate in arsenic trioxide injection by dual detection ion chromatography.

This paper describes a rapid method to determine arsenite assay and arsenate impurity in Arsenic Trioxide Injection using a single conductivity detector. The arsenite assay was determined in a non-suppressed conductivity detection mode and arsenate impurity was quantified in a suppressed conductivity detection mode. Dual-conductivity detections were enabled by valve switching and time programming.