Publications by authors named "M R Haghshenas"
Background And Aims: Overexpression of MexXY-OprM efflux pump causes resistance to aminoglycosides in . We aimed to investigate the relationship between resistance to aminoglycosides and the MexXY-OprM expression level in clinical isolates without and after treatment with curcumin and/or phenylalanine-arginine-beta-naphthylamide (PAβN) as the efflux pump inhibitors.
Methods: We collected 100 clinical isolates from hospitalized patients.
High Expression of Immune Checkpoint Molecules in Different Types of Thyroid Cancer.
Iran J Allergy Asthma Immunol
October 2024
Article Synopsis
- * Samples from 100 patients with various types of thyroid carcinoma were analyzed, revealing high levels of PD-1 in tumor-infiltrating lymphocytes (88%) and PD-L1 in tumor cells (30%).
- * Findings showed that increased PD-1 and PD-L1 expression correlates with advanced disease stages and may indicate potential for targeted immunotherapy, particularly in anaplastic thyroid carcinoma.
Background: Bladder cancer is one of the most common cancers in the world and is associated with high treatment costs and mortality. The role of different enzymes and molecules in this cancer has been the subject of extensive research in recent years. Among these, the role of metabolic enzymes such as FASN and LDH has been studied less than others.
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- The research investigates the effects of crocin and crocetin on B-cell lymphoma induced by Epstein Barr Virus (EBV), comparing them to the standard treatment, cyclophosphamide.
- The study involved treating infected cell lines with varying concentrations of the compounds and measuring their impact on cell viability and apoptosis, alongside monitoring specific miRNA expressions.
- Findings revealed that crocin and crocetin effectively reduced cell proliferation and increased apoptosis, but did not affect the levels of miRNA-16-1 during treatment.
Background And Purpose: Breast cancer is the most common type of cancer and one of the major causes of death among women. Many reports propose gallic acid as a candidate for cancer treatment due to its biological and medicinal effects as well as its antioxidant properties. This study aimed to assess the effects of metformin and gallic acid on human breast cancer (MCF-7) and normal (MCF-10) cell lines.
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