Publications by authors named "M R Habibi"
Neoadjuvant Endocrine Therapy Compared to Neoadjuvant Chemotherapy in Node-Positive HR+, HER2- Breast Cancer (Nodal pCR and the Rate of ALND): A Systematic Review and Meta-Analysis.
Breast J
January 2025
Article Synopsis
- Patients with HR+, HER2- breast cancers have lower responses to neoadjuvant therapy, and this study examines the effectiveness of neoadjuvant endocrine therapy (NET) in these patients.
- A total of 18,037 patients participated in the study, with 3,707 receiving NET and 14,330 receiving neoadjuvant chemotherapy (NAC), with NET patients being older on average (64.1 vs. 47.6 years).
- Results showed that node pathologic complete response (pCR) rates were 8.9% for NET compared to 14.9% for NAC, and axillary lymph node dissection (ALND) rates were also lower for NET patients (39.1%
Glutathione (GSH) is a bioactive tripeptide with important physiological functions in animals, plants, and microorganisms. GSH participates in various biochemical reactions in vivo and is known for its antioxidant, anti-allergy, and detoxification properties. This study introduces an innovative photoelectrochemical (PEC) method for GSH detection, leveraging a fluorine-doped tin oxide (FTO) electrode enhanced by TiO nanoflowers and graphitic carbon nitride quantum dots (g-CNQDs).
View Article and Find Full Text PDFInhibition of mitochondrial pyruvate transport via the mitochondrial pyruvate carrier (MPC) has shown beneficial effects in treating metabolic diseases, certain cancers, various forms of neurodegeneration, and hair loss. These benefits arise either from the direct inhibition of mitochondrial pyruvate metabolism or from the metabolic rewiring when pyruvate entry is inhibited. However, current MPC inhibitors are either nonspecific or possess poor pharmacokinetic properties.
View Article and Find Full Text PDFBackground: The adverse effects of aspirin are dose-dependent, and there is controversy surrounding the use of low-dose (LD) aspirin to prevent venous thromboembolism (VTE) following total joint arthroplasty (TJA). This meta-analysis sought to compare the efficacy and complication rate of low-dose (162 mg per day) versus high-dose (HD, 650 mg per day) aspirin after TJA surgery.
Methods: In four main databases, we searched from inception until September 2024 for articles comparing the rate of VTE following TJA(TKA/THA) using only aspirin chemoprophylaxis with different dosages.