Publications by authors named "M R Gismondo"
Which patients should be monitored for coinfections or should receive empirical antibiotic treatment, in patients with an acute viral respiratory infection, is largely unknown. We evaluated the prevalence, characteristics, outcomes of coinfected patients, and risk factors associated with a coinfection among patients with an acute viral infection. A retrospective, single-center study recruited consecutive patients from October 2022 to March 2023 presenting to the emergency department with signs of a respiratory tract infection.
View Article and Find Full Text PDFBacterial infections pose significant global health challenges, often underestimated due to difficulties in accurate diagnosis, especially when culture-based diagnostics fail. This study assesses the effectiveness of 16S-based metagenomic next generation sequencing (NGS) for identifying pathogens in culture-negative clinical samples across various medical settings. Overall, 48% of samples were collected from orthopedics, 15% from neurosurgery, and 12% in cardiac surgery, among others.
View Article and Find Full Text PDFHigh-throughput peptide array analysis and computational techniques for serological profiling of flavivirus infections: Implications for diagnostics and vaccine development.
J Med Virol
September 2024
Article Synopsis
- Arthropod-borne viruses like dengue virus (DENV) are a major global health issue, infecting around 400 million people annually and causing outbreaks even in non-endemic regions.
- The study aimed to improve serological diagnosis and identify new drugs by mapping immunogenic protein regions of DENV through high-density peptide arrays and computational methods.
- Twenty-four specific peptides were found that could distinguish DENV from other flaviviruses, with two peptides potentially serving as a serum biomarker for DENV infection, which may aid in developing diagnostic and preventative strategies.