Publications by authors named "M R Del Bigio"
Article Synopsis
- A woman developed four brain tumors (meningiomas) after 11 years of taking the synthetic progesterone drug megestrol.
- After stopping the medication at age 75, her health improved and scans showed significant tumor reduction by age 78.
- An autopsy at age 83 revealed both tumor remnants with specific hormonal receptors and fatty tissue, marking the first detailed study of this phenomenon following progestin discontinuation.
Magnetic Resonance Imaging (MRI) is commonly used to follow the progression of neurodegenerative conditions, including multiple sclerosis (MS). MRI is limited by a lack of correlation between imaging results and clinical presentations, referred to as the clinico-radiological paradox. Animal models are commonly used to mimic the progression of human neurodegeneration and as a tool to help resolve the paradox.
View Article and Find Full Text PDFMature multiciliated ependymal cells line the cerebral ventricles where they form a partial barrier between the cerebrospinal fluid (CSF) and brain parenchyma and regulate local CSF microcirculation through coordinated ciliary beating. Although the ependyma is a highly specialized brain interface with barrier, trophic, and perhaps even regenerative capacity, it remains a misfit in the canon of glial neurobiology. We provide an update to seminal reviews in the field by conducting a scoping review of the post-2010 mature multiciliated ependymal cell literature.
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- A 13-year-old boy with optic pathway/hypothalamic glioma developed slipped capital femoral epiphysis (SCFE) after being treated with the FGFR TKI inhibitor erdafitinib.
- Following treatment, he experienced knee pain, which led to the diagnosis of SCFE via X-ray.
- After stopping erdafitinib and having surgery for his hip, the boy's tumor size decreased significantly, emphasizing the importance of monitoring for skeletal side effects in pediatric patients on pan-FGFR TKIs.