Antimicrobial Resistance Surveillance in Human Pathogens in Ahmedabad: A One-Year Prospective Study.

Antimicrobial resistance (AMR) is an escalating global concern, particularly in developing countries like India. A 1-year prospective study was conducted on AMR in human pathogens from Ahmedabad, India. The study aimed to generate an evidence-based database on the AMR profile of pathogens in this region.

Comprehensive computational investigation for ligand recognition and binding dynamics of SdiA: a degenerate LuxR -type receptor in Klebsiella pneumoniae.

SdiA is a LuxR-type receptor that controls the virulence of Klebsiella pneumoniae, a Gram-negative bacterium that causes various infections in humans. SdiA senses exogenous acyl-homoserine lactones (AHLs) and autoinducer-2 (AI-2), two types of quorum sensing signals produced by other bacterial species. However, the molecular details of how SdiA recognizes and binds to different ligands and how this affects its function and regulation in K.

Potential dual inhibition of SE and CYP51 by eugenol conferring inhibition of Candida albicans: Computationally curated study with experimental validation.

Ergosterol is the key sterol component in the cell membrane of fungi including moulds and yeasts. Any decrease in the levels of ergosterol in the cell membrane of fungi render them venerable to cell membrane damage and even its death. Majority of antifungal drug targets the key enzymes involved in ergosterol biosynthesis pathway.

Effect of enzyme pretreatment on dehulling, cooking time and protein content of pigeon pea (variety BDN2).

This study was carried out to investigate the effect of enzymatic pretreatment at different enzyme concentration, incubation time, incubation temperature and tempering water pH on the hulling efficiency, cooking quality and protein content of pigeon pea (variety BDN2). Response surface methodology based on a four-factor, five-level, central composite design was employed to study the effect of the independent variables and optimize processing conditions. A quadratic model satisfactorily described the hulling efficiency, cooking time and protein content with high value for the coefficient of determination R (0.