Publications by authors named "M R Cucinelli"
A new challenge for urinary free light chains: assessment of the upper reference limit in healthy subjects.
Eur Rev Med Pharmacol Sci
September 2023
Objective: Free light chains (FLCs) can be measured in both urine (uFLC) and serum (sFLC) in immunochemistry. We aim to compare FLC levels in serum and urine assessed among healthy volunteers and measured upper reference limits (URLs) of urinary FLC to creatinine ratio (uFLC/uCr) in mg/g to compare with the manufacturer's recommended URLs.
Patients And Methods: Eligibility criteria: normal serum and urine FLC measure and negative serum/urinary immunofixation.
Article Synopsis
- The study focuses on the objectives and methodology for testing Cryofibrinogen (CF), a protein that behaves abnormally at different temperatures, highlighting its relevance in clinical diagnostics, especially in rheumatology.
- A retrospective analysis from 2019 to 2021 indicates that most CF test requests came from the rheumatology department, with a significant number of patients testing positive for CF, while isolated CF cases were notably high among those with systemic sclerosis.
- The findings suggest that the established testing protocols can help create standardized recommendations for CF analysis, emphasizing the need to include CF testing in assessments for conditions that may lead to cryofibrinogenemia.
Article Synopsis
- The kappa index (K-Index) measures intrathecal immunoglobulin synthesis using a specific ratio of cerebrospinal fluid (CSF) and serum markers, but there's little data on how consistent these measurements are across different labs.
- In a study involving 15 paired CSF and serum samples analyzed by eight laboratories, there was excellent agreement in CSF KFLC measurements and good agreement in serum KFLC across different testing methods.
- The concordance for positive K-Index results was substantial overall and very good among certain laboratories, indicating that patients are unlikely to receive conflicting results regarding K-Index positivity despite variations in testing techniques.
Survival of pancreatic cancer is improved by surgery and is related to R0 resection. An accurate diagnosis and a careful staging are mandatory. Differential diagnosis must be estabilished between the different pancreatic lesions as carcinoma, chronic pancreatitis, cystic or endocrine neoplasms.
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