Publications by authors named "M R Cowie"
Article Synopsis
- Wearable accelerometers provide a way to continuously monitor physical activity in patients with heart failure, which could be useful for assessing treatment effects.
- In the DETERMINE trials, a subgroup of patients wore accelerometers at different points while also completing questionnaires and walking tests to evaluate their functional status.
- Results showed that lower activity levels were associated with worse health scores and measures, but overall, the relationships between accelerometer data and health assessments were generally weak, suggesting accelerometers could offer additional insights beyond traditional methods.
Where Do Plasma Biomarkers fit in With Current Alzheimer's Disease Detection?
Am J Geriatr Psychiatry
October 2024
Objectives: We examine the clinical utility of plasma-based detection for Alzheimer's disease (AD) pathophysiology in older adults with mild cognitive impairment (MCI) and whether cognitive screening can inform when to use plasma-based AD tests.
Methods: Seventy-four community-dwelling older adults with MCI had testing with plasma phosphorylated tau (p-tau) 217 and 181, positron emission tomography (PET) imaging for amyloid beta (Aβ), and cognitive assessment. Receiver operating characteristic (ROC) analysis was used to assess the diagnostic value of plasma p-tau.
Spatially resolved random telegraph fluctuations of a single trap at the Si/SiO interface.
Proc Natl Acad Sci U S A
October 2024
We use electrostatic force microscopy to spatially resolve random telegraph noise at the Si/SiO interface. Our measurements demonstrate that two-state fluctuations are localized at interfacial traps, with bias-dependent rates and amplitudes. These two-level systems lead to correlated carrier number and mobility fluctuations with a range of characteristic timescales; taken together as an ensemble, they give rise to a [Formula: see text] power spectral trend.
View Article and Find Full Text PDFCardiovascular clinical trials continue to under-represent children, older adults, females and people from ethnic minority groups relative to population disease distribution. Here we describe strategies to foster trial representativeness, with proposed actions at the levels of trial funding, design, conduct and dissemination. In particular, trial representativeness may be increased through broad recruitment strategies and site selection criteria that reflect the diversity of patients in the catchment area, as well as limiting unjustified exclusion criteria and using pragmatic designs that minimize research burden on patients (including embedded and decentralized trials).
View Article and Find Full Text PDFArticle Synopsis
- Pain is a key reason people seek medical help, but medical schools often lack thorough pain education; this project aimed to create a comprehensive pain curriculum across various campuses.
- An interdisciplinary Pain Working Group was formed to evaluate and improve existing pain competencies, ultimately identifying 33 target competencies, including specific ones for Indigenous Māori and Pacific Island communities.
- The curriculum emphasizes the importance of integrating cultural contexts, particularly in Aotearoa New Zealand, and aims to enhance pain learning by blending local needs with international best practices.