Quality of life in patients with spinal muscular atrophy in Brazil: patient self-assessment and carer perception.

Objectives: The aim of this study was to assess the perception of quality of life of patients with spinal muscular atrophy (SMA) and investigate whether there is a correlation between patients' perception and that of their carers.

Methods: Cross-sectional analytical observational study. In the first part, socioeconomic, demographic, clinical, and treatment information were collected from patients diagnosed with SMA, regardless of type, sex, or age.

Social media activism and women's health: Endometriosis awareness and support.

Objective: While endometriosis is estimated to affect 1 in 10 women globally, awareness of the disease as well as research and funding to fight the disease remains lacking as compared with other chronic diseases. This study examines how social media users utilized Instagram to raise awareness of and mobilize activism around endometriosis by analyzing prominent topics, word associations, and feminism themes in endometriosis-tagged posts on Instagram.

Methods: We used a mixed-method approach of combining computational analyses (topic modeling and word association) and human coding (qualitative thematic analysis) of Instagram posts on endometriosis.

Liposomal Formulation of an Organogold Complex Enhancing Its Activity as Antimelanoma Agent-In Vitro and In Vivo Studies.

The therapeutic management of melanoma, the most aggressive form of skin cancer, remains challenging. In the search for more effective therapeutic options, metal-based complexes are being investigated for their anticancer properties. Cisplatin was the first clinically approved platinum-based drug and, based on its success, other metals (e.

Ambient temperature and deaths from homicide in Brazil during 2010-2019: A nationwide space-time-stratified case-crossover study.

Research Question: Previous evidence suggests a positive association between temperature and homicide, but the association was less clear in Brazil where homicide is one of the leading causes of death. This study aimed to quantify the association between ambient daily temperature and homicides in Brazil with potential lag effects and to quantify the temperature attributed fractions of homicides in Brazil.

Methods: A space-time-stratified case-crossover design with distributed lag models was used to evaluate the temperature-homicide association from 1·1·2010 to 31·12·2019 in Brazil.