Association between T2 relaxation time and biomechanical loading of the anterior cruciate ligament in healthy individuals.

Anterior cruciate ligament (ACL) injury is common in sports that include 'change in direction' tasks. The aim of the current study was to determine the association between T2 relaxation time (an indicator of ACL integrity) of the distal portion of the ACL sub-region, biomechanical loading factors of the ACL, sex, and sport status of the participants. Participants between 18 to 35 years performed unanticipated 'change in direction' trials at their maximal self-preferred speed.

Running Distance and Biomechanical Risk Factors for Plantar Fasciitis: A 1-yr Prospective 4HAIE Cohort Study.

Introduction: Plantar fasciitis (PF) is one of the most common running-related injuries.

Purpose: The aim of this prospective study was to determine the incidence of PF and identify potential risk or protective factors for PF in runners and non-runners.

Methods: Data from 1206 participants from the 4HAIE cohort study (563 females/643 males; 715 runners/491 non-runners; 18-65 yr of age) were included in the analysis.

Recurrent Neural Network GO-GARCH Model for Portfolio Selection.

We develop a hybrid model of multivariate volatility that uses recurrent neural networks to capture the conditional variances of latent orthogonal factors in a GO-GARCH framework. Our approach seeks to balance model flexibility with ease of estimation and can be used to model conditional covariances of a large number of assets. The model performs favourably in comparison with relevant benchmark models in a minimum variance portfolio (MVP) scenario.

Time in Therapeutic Range of Unfractionated Heparin-Based Therapy in Critically Ill Patients with COVID-19 Pneumonia.

Purpose: Anticoagulation therapy aims to improve the outcome of critically ill patients with severe COVID-19-associated pneumonia. Activated partial thromboplastin time (aPTT) is commonly used to maintain the target therapeutic range of continuous infusion of unfractionated heparin (UFH). The UFH infusion efficacy can be evaluated by determining the time in therapeutic range (TTR) using a modified Rosendaal method.

Role of Alveolar-Arterial Difference in Estimation of Extravascular Lung Water in COVID-19-Related ARDS.

Background: The dominant feature of COVID-19-associated ARDS is gas exchange impairment. Extravascular lung water index is a surrogate for lung edema and reflects the level of alveolocapillary disruption. The primary aim was the prediction of extravascular lung water index by the alveolar-arterial oxygen difference.