Publications by authors named "M R Bullock"
Background: The COVID-19 pandemic accelerated a shift to decentralized clinical trials. We present the potential feasibility of this approach from a phase 1 pharmacokinetic (PK) trial.
Methods: Healthy adults (18-55 years) with a body mass index of 19.
The orphan nuclear receptor Nr4a1 has complex biological functions and has been implicated in numerous diseases, including cardiovascular disease. While protective in atherosclerosis and myocardial ischemia, Nr4a1 has been shown to cause cardiac fibrosis in non-ischemic adverse remodeling of the heart. However, mechanisms underlying these actions are still poorly understood.
View Article and Find Full Text PDFLiquid biopsies are a minimally invasive approach to obtain biomarkers including cell-free DNA (cfDNA) from peripheral blood. To date, there are limited and conflicting studies evaluating their role in thyroid cancer. Our study evaluated the utility of cfDNA in advanced thyroid cancers.
View Article and Find Full Text PDFArticle Synopsis
- Sexual minority men, particularly Black sexual minority men, face significant health disparities, including disproportionate rates of methamphetamine use, due to structural barriers and racism.
- The HISTORY study aims to explore how exposure to structural racism and discrimination impacts methamphetamine use among this population in Atlanta, Georgia, and seeks to identify effective interventions.
- Utilizing a mixed methods approach over five years, the study will gather both quantitative and qualitative data to understand these dynamics and develop actionable recommendations for reducing methamphetamine use in Black sexual minority men.
Article Synopsis
- Computer-vision and machine-learning techniques are being utilized to evaluate mouse behavior in Alzheimer's disease models, using a method called variational animal motion embedding (VAME).
- Significant changes in behavior were observed in Alzheimer’s models, such as age-related differences and increased randomness in actions.
- Intervention by blocking certain neuroinflammation processes largely mitigated these behavioral changes, highlighting the impact of neuroinflammation on spontaneous behavior in Alzheimer's disease.