Publications by authors named "M R Bonner"

Multi-drug delivery systems have gained increasing interest from the pharmaceutical industry. Alongside this is the interest in amorphous solid dispersions as an approach to achieve effective oral delivery of compounds with solubility-limited bioavailability. Despite this, there is limited information regarding predicting the behavior of two or more drugs (in amorphous forms) in a polymeric carrier and whether molecular interactions between the compounds, between each compound, and if the polymer have any effect on the physical properties of the system.

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Article Synopsis
  • Gene therapy using elivaldogene autotemcel (eli-cel) has shown effectiveness in treating cerebral adrenoleukodystrophy but raises concerns about cancer risks.
  • Research analyzed blood and bone marrow samples from patients who received eli-cel to evaluate integration sites and other genetic factors.
  • Out of 67 patients treated, 7 developed hematologic cancers, with multiple instances linked to lentiviral vector insertions, though some patients successfully underwent stem cell transplantation and remained symptom-free.
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Chlorpyrifos (CPF) is a widely used organophosphate insecticide that has been linked to detrimental health effects that range from neurological impacts to respiratory disease. The objective of this study was to assess respiratory symptoms associated with CPF exposure throughout the application season. Urine samples were collected from Egyptian adolescent applicators ( = 206) and non-applicators ( = 72) to assess 3,5,6-trichloro-2-pyridinol (TCPy), a biomarker for CPF exposure, along with spirometry measures to determine lung ventilatory function.

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Number perception emerges from multiple stages of visual processing. Understanding how systematic biases in number perception occur within a hierarchy of increasingly complex feature representations helps uncover the multistage processing underlying our visual number sense. Recent work demonstrated that reducing coherence of low-level visual attributes, such as color and orientation, systematically reduces perceived number.

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