Publications by authors named "M R Bacarelli"
Article Synopsis
- The study evaluated the diagnostic accuracy of anti-cN1A antibodies for inclusion body myositis (IBM) by comparing two testing methods: line immunoassay (LIA) and enzyme-linked immunoassay (ELISA).
- Out of 340 patients, only 5.88% tested positive for anti-cN1A, but the majority did not have IBM, indicating low specificity for this condition.
- Findings showed strong agreement between LIA and ELISA results, suggesting that LIA could be a faster alternative, but anti-cN1A cannot be deemed a reliable biomarker for IBM due to overlap with other diseases.
Background: In ∼50% of severe atrioventricular blocks (AVBs) occurring in adults <50 years, the underlying etiology remains unknown. Preliminary evidence from case reports suggests that autoimmunity, specifically the presence of circulating anti-Ro/SSA antibodies in the patient (acquired form), in the patient's mother (late-progressive congenital form), or in both (mixed form), could be involved in a fraction of idiopathic AVBs in adults by possibly targeting the L-type calcium channel (Ca1.2) and inhibiting the related current (I).
View Article and Find Full Text PDFIntroduction: Based on ACR/EULAR classification criteria, minor salivary glands biopsy (MSGB) is a useful diagnostic tool for the diagnosis of primary Sjögren's syndrome (SS). The main objective of our study was to evaluate the diagnostic role of MSGB, as well as to highlight correlations between histological findings and autoimmune profiles.
Material And Methods: We retrospectively evaluated histological and autoimmunity data from patients who underwent MSGB in our department in cases of suspected SS, from March 2011 to December 2018.
Anti-double-stranded DNA antibodies (anti-dsDNA) are considered a specific marker for systemic lupus erythematosus (SLE). Though the Farr technique was once the reference method for their detection, it has been almost entirely replaced by more recently developed assays. However, there is still no solid evidence of the commutability of these methods in terms of diagnostic accuracy and their correlation with the Crithidia luciliae immunofluorescence test (CLIFT).
View Article and Find Full Text PDFArticle Synopsis
- Autoantibodies against extractable nuclear antigens (ENA) are essential for diagnosing systemic autoimmune rheumatic diseases (SARD), and new methods allow for simultaneous detection of multiple anti-ENA reactivities.
- The study compared eight different immunoassays on sera from 60 SARD patients, 10 inflammatory arthritis patients, and 10 healthy donors to assess their sensitivity, specificity, and diagnostic accuracy.
- Results showed good agreement among methods (average kappa of 0.82) and high specificity, but there were notable differences in analytical sensitivity, highlighting the need for clinicians to understand the diagnostic capabilities of the assays used.