Comparison between azithromycin and amoxicillin in the treatment of infectious exacerbation of chronic obstructive pulmonary disease.

Objective: To compare the efficacy, safety, and tolerability of azithromycin and amoxicillin in the treatment of patients with infectious exacerbation of chronic obstructive pulmonary disease.

Methods: This study was conducted at six medical centers across Brazil and included 109 patients from 33 to 82 years of age. Of those, 102 were randomized to receive either azithromycin (500 mg/day for three days, n = 49) or amoxicillin (500 mg every eight hours for ten days, n = 53).

Cefodizime given in single or divided doses for the treatment of lower respiratory tract infection.

The safety and efficacy of two dose regimens of cefodizime (CAS 69739-16-8, HR 221) in hospitalized patients with lower respiratory tract infections were assessed in two consecutive studies. Sputum bacteriology, chest X-ray and a safety laboratory check were performed at baseline and after therapy. In order to compensate for the lack of a double-blind design the evaluation was conducted as a clinical intention-to-treat analysis.

Syngamosis: two new Brazilian cases and evidence of a possible pulmonary cycle.

Cases of syngamosis due to Mammomanogamus laryngeus are reported, with a discussion of diagnostic aspects. A pulmonary cycle for M. laryngeus is proposed, suggested by the appearance of a transient area of homogeneous consolidation of the lung, detected by X-ray.