Publications by authors named "M Quintiliani"
Objective: Fenfluramine (FFA), stiripentol (STP), and cannabidiol (CBD) are approved add-on therapies for seizures in Dravet syndrome (DS). We report on the long-term safety and health care resource utilization (HCRU) of patients with DS treated with FFA under an expanded access program (EAP).
Methods: A cohort of 124 patients received FFA for a median of 2.
Background/objectives: Mesothelioma is an aggressive cancer with limited treatment options. Mesothelioma therapy often involves a multimodal approach including surgery, radiotherapy and chemotherapy. However, the prognosis for patients remains poor.
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- The hepatitis E virus (HEV) is a rising public health concern primarily caused by contaminated food or water and has sporadic human-to-human transmission through transfusions or transplants.
- Domestic pigs are the primary reservoirs for the virus, while wild boars contribute minimally due to their smaller populations and limited product consumption, making their role in disease spread often underestimated.
- The review aims to provide a comprehensive analysis of HEV, focusing on wild boars and emphasizing an interdisciplinary "One Health" approach, drawing on various scientific literature to discuss epidemiology, transmission, clinical implications, and infection control measures.
Article Synopsis
- The central nervous system (CNS) relies on the interaction between glial cells and neurons for essential functions like development, communication, and maintaining brain health.
- Glial cells, such as astrocytes and microglia, play a crucial role in neuroinflammation during brain disorders and can either promote or inhibit inflammation through their responses to brain damage.
- Extracellular vesicles (EVs) released by glial cells are key in mediating communication and responses in neuroinflammatory conditions, impacting neurodegenerative diseases by either exacerbating or alleviating toxic effects on neurons.
Neoplastic transformation reprograms tumor and surrounding host cell metabolism, increasing nutrient consumption and depletion in the tumor microenvironment. Tumors uptake nutrients from neighboring normal tissues or the bloodstream to meet energy and anabolic demands. Tumor-induced chronic inflammation, a high-energy process, also consumes nutrients to sustain its dysfunctional activities.
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