Publications by authors named "M Quinkler"
Objective: To study pregnancy outcomes and complications in women with congenital adrenal hyperplasia (CAH).
Methods: A retrospective multicenter study was conducted at tertiary reference centers in 5 countries (Austria, Germany, Italy, Sweden, USA), including 72 adult women with CAH (nonclassic [NC] n = 34, simple virilizing [SV] n = 21, salt wasting [SW] n = 17).
Results: A total of 133 pregnancies, 112 live births, and 25 abortions were documented.
Article Synopsis
- Patients with primary aldosteronism (PA) accompanied by autonomous cortisol co-secretion (ACS) show worse cardiac outcomes and left ventricular hypertrophy compared to those without ACS.
- A study of 367 PA patients indicated that those with ACS had higher NTpro-BNP levels, which correlate with cortisol levels, signifying more cardiac stress initially and less recovery post-treatment.
- Over time, only patients without ACS showed significant improvements in heart dimensions and mass, emphasizing the long-term impact of ASC on cardiac health in PA patients.
MAML3-fusions modulate vascular and immune tumour microenvironment and confer high metastatic risk in pheochromocytoma and paraganglioma.
Best Pract Res Clin Endocrinol Metab
December 2024
Pheochromocytomas and paragangliomas are rare neuroendocrine tumours. Around 20-25 % of patients develop metastases, for which there is an urgent need of prognostic markers and therapeutic stratification strategies. The presence of a MAML3-fusion is associated with increased metastatic risk, but neither the processes underlying disease progression, nor targetable vulnerabilities have been addressed.
View Article and Find Full Text PDFContext: Acromegaly is a rare disease caused by excessive growth hormone (GH) secretion, mostly induced by pituitary adenomas. The care of pregnant women with acromegaly is challenging, in part due to existing clinical data being limited and not entirely consistent with regard to potential risks for mother and child.
Objective: To retrospectively examine data on pregnancy and maternal as well as neonatal outcomes in patients with acromegaly.
Objective: Patients with congenital adrenal hyperplasia (CAH) require life-long glucocorticoid replacement, including stress dosing (SD). This study prospectively assessed adrenal crisis (AC) incidence, frequency, and details of SD and disease knowledge in adult and paediatric patients and their parents.
Design: Prospective, observational study.