The Malignant Transformation of Viral Hepatitis to Hepatocellular Carcinoma: Mechanisms and Interventions.

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality globally, predominantly associated with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. These infections drive persistent liver inflammation, culminating in cellular dysregulation, fibrosis, and cancer. Despite advancements in targeted therapies, drug resistance and the lack of reliable biomarkers for patient stratification still terribly hinder the treatment of viral HCC.

Culling-based Real-time Rendering with Accurate Ray Sampling for High-resolution Light Field 3D Display.

Real-time rendering for light field displays (LFDs) enables human-computer three-dimensional (3D) interaction with smooth and realistic experience, which is potentially useful for 3D gaming, virtual reality, or surgical navigation. However, existing rendering methods realize a real-time rendering normally by sacrificing the 3D image resolution. We propose a culling-based real-time rendering (CBR) method with an accurate ray sampling, aimed at rendering the optimal synthetic images in real-time, which reproduce the high resolution 3D images.

[Efficacy of chemo-free regimen in treatment of six patients with treatment-naive Philadelphia chromosome-positive mixed phenotype acute leukemia].

To investigate the efficacy of chemo-free regimen in treatment of patients with treatment-naive Philadelphia chromosome positive mixed phenotype acute leukemia(PhMPAL). The clinical data of patients with newly treated PhMPAL who received venetoclax (VEN), azacytidine (AZA) and tyrosine kinase inhibitors (TKIs) in the First Affiliated Hospital of Soochow University from July 1, 2021 to October 31, 2023 were retrospectively included. The last follow-up date was December 1, 2024.

Septin AoCDC11 is involved in trap morphogenesis, conidiation, and vegetative growth in carnivorous Arthrobotrys oligospora.

Septins, a conserved family of cytoskeletal proteins with GTP-binding domains, play key roles in cell polarity, morphogenesis, cytoskeleton organization, and membrane remodeling. The nematode-trapping fungus Arthrobotrys oligospora can capture and kill nematodes using adhesive networks. It has been highlighted the importance of cell polarity, actin organization, and membrane remodeling in the process of trap formation, but the role of septins in adhesive-network forming remains unclear.

Exosomal lncRNA Mir100hg from lung cancer stem cells activates H3K14 lactylation to enhance metastatic activity in non-stem lung cancer cells.

The mean survival of metastatic lung adenocarcinoma is less than 1 year, highlighting the urgent need to understand the mechanisms underlying its high mortality rate. The role of Extracellular vesicles (EVs) in facilitating the interactions between cancer cells and the metastatic microenvironment has garnered increasing attention. Previous studies on the role of EVs in metastasis have been primarily focused on cancer cell-derived EVs in modulating the functions of stromal cells.