Decoding tinnitus progression: neurochemical shifts in the anterior cingulate cortex revealed by magnetic resonance spectroscopy.

Background: Tinnitus persists as a significant public health challenge with elusive neurochemical underpinnings. Emerging evidence implicates dysregulated excitatory-inhibitory neurotransmission in the anterior cingulate cortex (ACC), a limbic-auditory hub governing tinnitus salience. This study investigates dynamic ACC neurochemical changes during tinnitus progression.

Comparative analysis of perioperative renal function in patients undergoing heart transplantation and left ventricular assist device implantation: a multicenter retrospective study.

Background: Renal function is a crucial factor affecting the prognosis of patients with end-stage heart failure (HF). The differential impacts of heart transplantation and left ventricular assist device (LVAD) implantation on renal function are unclear. Therefore, we compared the perioperative renal function changes in patients who underwent heart transplantation with that of patients who underwent LVAD implantation.

Hypoxia tolerance determine differential gelsenicine-induced neurotoxicity between pig and mouse.

Background: Gelsemium elegans (G. elegans) is widely recognized as one of the most toxic plants globally, particularly harmful to humans. Some reports indicate that it is non-toxic to pigs and even has a growth-promoting effect; however, the underlying reasons for this paradox remain unclear.

SVLearn: a dual-reference machine learning approach enables accurate cross-species genotyping of structural variants.

Structural variations (SVs) are diverse forms of genetic alterations and drive a wide range of human diseases. Accurately genotyping SVs, particularly occurring at repetitive genomic regions, from short-read sequencing data remains challenging. Here, we introduce SVLearn, a machine-learning approach for genotyping bi-allelic SVs.

Prediction of central line-associated bloodstream infection: focus on time of insertion.

Objective: Central line-associated bloodstream infections (CLABSIs) result in morbidity and mortality among hospitalized patients. Hospital interventions to reduce the incidence of CLABSI are often broadly applied to all patients with central venous access. Identifying central lines at high risk for CLABSI at time of insertion will allow for a more focused delivery of preventative interventions.