Publications by authors named "M Puolakkainen"
Background/aim: Pelvic inflammatory disease (PID) is a risk factor for epithelial ovarian cancer (EOC). Chlamydia trachomatis infection, a major cause of PID, may persist in some women. Serum IgG antibodies to chlamydial TroA and HtrA are more common in ascending or repeat chlamydial infection than in uncomplicated infection.
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- In 2020, the International Committee on Systematics of Prokaryotes (ICSP) rejected a proposal to change the naming rules for prokaryotes to include gene sequences as a basis for nomenclature.
- In 2022, an alternative naming system called SeqCode was introduced, allowing genome sequences to be used for naming species.
- The ICSP's taxonomy subcommittee believes that using gene sequences could improve naming for hard-to-culture microorganisms, like chlamydiae, and suggests registering new names for uncultured prokaryotes in the SeqCode registry.
is the most common cause of bacterial sexually transmitted infections and causes serious reproductive tract complications among women. The limitations of existing oral antibiotics and treatment of antimicrobial resistance require alternative treatment options. We are proposing, for the first time, the natural polyphenol resveratrol (RES) in an advanced delivery system comprising liposomes incorporated in chitosan hydrogel, for the localized treatment of infection.
View Article and Find Full Text PDFBackground: Four new variants of Chlamydia trachomatis (nvCTs), detected in several countries, cause false-negative or equivocal results using the Aptima Combo 2 assay (AC2; Hologic). We evaluated the clinical sensitivity and specificity, as well as the analytical inclusivity and exclusivity of the updated AC2 for the detection of CT and Neisseria gonorrhoeae (NG) on the automated Panther system (Hologic).
Methods: We examined 1004 clinical AC2 samples and 225 analytical samples spiked with phenotypically and/or genetically diverse NG and CT strains, and other potentially cross-reacting microbial species.