Publications by authors named "M Puntes"
Fat-binding nutraceutical supplements have gained considerable attention as potential cholesterol-lowering strategies to address dyslipidemia in overweight and obese individuals. This study aimed to evaluate the effects of a polysaccharide-rich compound containing β-glucan/chitin-chitosan (βGluCnCs) on lipid profiles and lipoprotein function. In a prospective, two-arm clinical trial, 58 overweight and obese individuals were randomized to receive either 3 g/day of βGluCnCs or a placebo (microcrystalline cellulose) for 12 weeks.
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- Bilastine is a non-sedating antihistamine effective for treating allergies, and this study aimed to compare its different formulations (i.v., i.m., and oral) against dexchlorpheniramine and placebo for their antihistamine activity and onset time.
- Conducted on 25 healthy adults, the study demonstrated that all bilastine formulations provided quick relief (15 min for i.v. and i.m., 30 min for oral) and significantly reduced allergic reactions compared to dexchlorpheniramine and placebo.
- The results showed that bilastine formulations were not only more effective but also safe, with no serious adverse events reported, while dexchlorpheniramine was
Aims: Probiotics with high bile salt hydrolase (BSH) activity have shown to promote cardiovascular health. However, their mechanism(s) of action remain poorly understood. Here, we performed a pilot exploratory study to investigate effects of a 4-week intervention with escalating doses of a BSH-active formula containing Lactiplantibacillus plantarum strains KABP011, KABP012, and KABP013 on bile acid (BA), lipid profile, and lipoprotein function.
View Article and Find Full Text PDFLack of Clinical Relevance of Bilastine-Food Interaction in Healthy Volunteers: A Wheal and Flare Study.
Int Arch Allergy Immunol
December 2022
Article Synopsis
- The study compared how food affects the pharmacodynamic activity of bilastine in healthy volunteers, showing that food impacts bilastine levels but not its effectiveness.
- Under both fasting and fed conditions, bilastine showed a decrease in blood concentration levels, but the antihistamine's effect remained consistent.
- Even with a slight delay in action when taken with food, bilastine's overall clinical efficacy was unaffected.
Background: The mechanisms through which kappa opioid receptor (KOR) agonists induce psychotomimetic effects are largely unknown, although the modulation of this receptor has attracted attention for its clinical use. In this work, we characterize the neuropharmacological effects of salvinorin-A, a highly selective KOR agonist.
Methods: Changes in multimodal electroencephalography, single-photon emission computed tomography, and subjective effects following the acute administration of salvinorin-A are reported.