Publications by authors named "M Pulley"
Article Synopsis
- ALS is a fast-progressing neurodegenerative disease with no cure and limited treatment options, creating a need for better therapies.
- A study was conducted to examine the effects of memantine on ALS progression and related cognitive and behavioral changes using a randomized, placebo-controlled trial with 89 participants.
- Results showed that memantine did not significantly affect the progression of ALS, biomarker changes, or neuropsychiatric symptoms compared to a placebo.
Article Synopsis
- A retrospective study was conducted on 28 childhood cancer survivors to assess their immunity after chemotherapy, specifically focusing on those who did not undergo hematopoietic stem cell transplantation.
- The study found lower rates of seropositivity for various vaccines (measles, mumps, rubella, varicella, hepatitis B) in these survivors compared to the general population, with the most significant drop in those with hematological cancers.
- The findings suggest that pediatric cancer survivors might need revaccination due to the loss of protective antibodies, highlighting the need for further research to establish guidelines for this group.
Primary lateral sclerosis natural history study - planning, designing, and early enrollment.
Amyotroph Lateral Scler Frontotemporal Degener
August 2023
Article Synopsis
- Primary lateral sclerosis (PLS) is a rare, misunderstood disease, but recent developments in biomarkers and potential treatments are changing the landscape of research.
- The PLS Natural History Study, spanning 30 sites over 24 months, aims to enroll 100 participants and uses a mix of smartphone-based assessments and in-person evaluations to track disease progression through the PLS Functional Rating Scale.
- Enrollment progress has been slower than expected, impacted by COVID-19 and the uniqueness of PLS, highlighting the need for innovative strategies to improve recruitment and research for rare diseases.
Background And Objectives: Myasthenia gravis (MG) is an autoimmune disease characterized by dysfunction at the neuromuscular junction. Treatment frequently includes corticosteroids (CSs) and IV immunoglobulin (IVIG). This study was conducted to determine whether immune globulin (human), 10% caprylate/chromatography purified (IGIV-C) could facilitate CS dose reduction in CS-dependent patients with MG.
View Article and Find Full Text PDFIntroduction/aims: It is unknown if patients with neuromuscular diseases prefer in-person or virtual telemedicine visits. We studied patient opinions and preference on virtual versus in-person visits, and the factors influencing such preferences.
Methods: Telephone surveys, consisting of 11 questions, of patients from 10 neuromuscular centers were completed.