Publications by authors named "M Promm"
Introduction: Previous assumptions suggested that the technique of approximation without osteotomy in primary exstrophy repair (PER) could only be applied in newborns and anticipated poorer outcomes. Recent studies indicated that this technique can be successfully executed not only in immediate PER but also yields favorable long-term results. Therefore, we evaluated and compared the orthopaedic and radiological long-term outcomes after pubic symphysis approximation without osteotomy in immediate and delayed PER.
View Article and Find Full Text PDFEuroGuiderm guideline on lichen sclerosus-Treatment of lichen sclerosus.
J Eur Acad Dermatol Venereol
October 2024
Article Synopsis
- Lichen sclerosus (LS) is a skin condition primarily affecting the anogenital area, causing symptoms like itching, soreness, and potential sexual and urinary dysfunction, with a risk of genital cancer and significant impacts on quality of life.
- The guideline aims to improve the diagnosis and treatment of LS, offering evidence-based recommendations for different therapies and care approaches, especially during pregnancy and follow-up.
- Topical corticosteroids are the primary treatment for LS in both sexes, with surgery as an option for males if standard treatments fail, while UV light therapy is suggested for non-genital LS, despite limited research.
EuroGuiderm guideline on lichen sclerosus-introduction into lichen sclerosus.
J Eur Acad Dermatol Venereol
October 2024
Article Synopsis
- Lichen sclerosus (LS) is an inflammatory skin condition primarily affecting the anogenital area, leading to symptoms like itching, soreness, and potentially serious complications such as urinary and sexual dysfunction, along with an increased risk of genital cancer.
- *The guideline aims to provide a comprehensive approach for diagnosing and treating LS, including recommendations for topical and surgical treatments, as well as care considerations for patients during pregnancy and ongoing management.
- *Topical corticosteroids are considered the standard treatment for LS, with additional options like emollients and, if ineffective, surgical interventions such as circumcision for males; UV light therapy is also suggested for non-genital forms of LS despite limited evidence.
Purpose: An overexpression of nerve growth factor (NGF) in the urothelium is discussed to lead to neuronal hyperinnervation of the bladder detrusor. The aim was to assess the sensory and sympathetic innervation of the detrusor in unclosed exstrophic bladders patients with known overexpression of NGF in the urothelium.
Methods: Full-thickness bladder biopsies were prospectively obtained from 34 infants at delayed primary bladder closure between 01/2015 and 04/2020.
Background: Lichen sclerosus (LS) is a chronic inflammatory condition mainly affecting genital skin. It causes distressing symptoms that impact daily quality of life (QoL). It causes progressive anatomical changes and a potential risk of cancer.
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