Publications by authors named "M Prochazkova-Carlotti"
Article Synopsis
- * Analysis of 94 CTCL patients revealed that specific genetic variations (SNPs) in the telomerase gene may contribute to the disease's occurrence and progression.
- * Findings suggest that post-transcriptional regulation of telomerase, including alterations in splicing patterns of transcripts, is crucial for CTCL development, indicating a potential target for therapeutic intervention.
Primary cutaneous large B-cell lymphoma, leg-type (PCLBCL-LT) is the most aggressive primary cutaneous B-cell lymphoma (PCBCL). Tumor microenvironment has a crucial role in tumor development, and tumor-infiltrating lymphocytes (TILs) can be targeted by immunotherapies. We characterized TILs in 20 PCBCLs to identify the tumor microenvironment features associated with clinical outcomes.
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- Cutaneous T-cell lymphoma (CTCL), including Sézary syndrome and mycosis fungoides, involves the abnormal accumulation of T lymphocytes in the skin.
- CTCL cells exhibit varied characteristics and express cell adhesion molecules like cutaneous lymphocyte antigen (CLA), which facilitates their movement and survival in the skin.
- Research shows that targeting CLA with a specific antibody (HECA-452) reduces the movement, proliferation, and tumor growth of CTCL cells, indicating that inhibiting CLA might offer a potential treatment strategy for CTCL patients.
Telomeric Repeat-containing RNA (TERRA) are long non-coding RNAs transcribed from telomeric DNA sequences from multiple chromosome ends. Major research efforts have been made to understand TERRA roles and functions in several physiological and pathological processes. We summarize herein available data regarding TERRA's roles in human cells and we report the first investigation in cutaneous T-cells lymphomas (CTCL) using real-time PCR.
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