Publications by authors named "M Priyanthi Kumarasinghe"
Article Synopsis
- - The study investigates the effectiveness of immunotherapy for gastrointestinal stromal tumors (GISTs) using humanized mouse models to better understand the tumor environment.
- - Researchers utilized a cancer vascular targeting peptide (VTP) to deliver the LIGHT protein into GIST tumors, which enhanced blood vessel function and oxygen levels, leading to an increase in human effector T cells within the tumors.
- - The findings suggest that targeting tumor blood vessels and promoting immune responses could improve treatment outcomes for GIST patients, especially since certain structures associated with better prognosis were observed in treated tumors.
Our objective is to review motives and barriers for non-reproductive, living substance of human origin (SoHO) donation, and to extend existing typologies beyond blood. The expansion of SoHO collection is currently unmatched by increased living donors. Thus, there is a critical need to understand how to effectively recruit and retain donors to ensure a sustainable supply of SoHO.
View Article and Find Full Text PDFIntroduction: Guidelines and other strategic documents were collated to understand the extent of the global use of terms postpartum and postnatal along with the duration and schedule of maternal care after delivery.
Methods: Postpartum care guidelines and strategies published in English, by international organisations including the World Health Organization, and countries in either the Organization for Economic Co-operation and Development or Group of 20 were included in this scoping review. All documents available online with unrestricted access and published before May 31, 2023, were included.
Introduction: Reconstitution of oral pediatric antibiotic suspension by primary caregivers plays an essential role in determining the overall health outcome of the child. Incorrect reconstitution techniques could lead to underdosing, overdosing, or introduction of infection. Underdosing could lead to non-resolving infection and antimicrobial resistance.
View Article and Find Full Text PDFMalignancies of upper gastrointestinal tract are aggressive, and most locally advanced unresectable and metastatic cancers are managed by a combination of surgery and neoadjuvant/adjuvant chemotherapy and radiotherapy. Current therapeutic recommendations include targeted therapies based on biomarker expression of an individual tumor. All G/gastro-esophageal junction (GEJ) cancers should be tested for HER2 status as a reflex test at the time of diagnosis.
View Article and Find Full Text PDF