Publications by authors named "M Pratap"
One major obstacle in designing a successful therapeutic regimen to combat COVID-19 pandemic is the frequent occurrence of mutations in the SARS-CoV-2 resulting in patient to patient variations. Out of the four structural proteins of SARS-CoV-2 namely, spike, envelope, nucleocapsid and membrane, envelope protein governs the virus pathogenicity and induction of acute-respiratory-distress-syndrome which is the major cause of death in COVID-19 patients. These effects are facilitated by the viroporin (ion-channel) like activities of the envelope protein.
View Article and Find Full Text PDFPurpose: 5-HT2AR exists in high and low affinity states. Agonist PET tracers measure binding to the active high affinity site and thus provide a functionally relevant measure of the receptor. Limited in vivo data have been reported so far for a comparison of agonist versus antagonist tracers for 5-HT2AR used as a proof of principle for measurement of high and low affinity states of this receptor.
View Article and Find Full Text PDFArticle Synopsis
- Automated label-free quantitative imaging, using digital holographic microscopy (DHM), enhances high throughput disease diagnosis by providing non-invasive structural details of cellular samples.
- A new region-recognition method combines shape recognition with iterative thresholding to optimize frequency component extraction, enabling fully automated adaptive filtering for various samples and imaging conditions.
- This technique significantly improves imaging through optically scattering biological materials and automatically extracts statistical differences in optical height between infected and uninfected red blood cells, promoting greater autonomy in DHM for live cell imaging.
Neuropeptide Y receptor type 5 (NPY5R) is a G-protein coupled receptor (GPCR) that belongs to the subfamily of neuropeptide receptors (NPYR) that mediate the action of endogenous neuropeptide Y (NPY). Animal models and preclinical studies indicate a role for NPY5R in the pathophysiology of depression, anxiety, and obesity and as a target of potential therapeutic drugs. To better understand the pathophysiological involvement of NPY5R, and to measure target occupancy by potential therapeutic drugs, it would be advantageous to measure NPY5R binding in vivo by positron emission tomography (PET).
View Article and Find Full Text PDFObjective: To examine the utility of single-photon emission computed tomography (SPECT) to predict conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD).
Design: Longitudinal, prospective study.
Setting: University-based memory disorders clinic.