Publications by authors named "M Poursadeghfard"
Genetics plays a significant role in Multiple Sclerosis (MS), with approximately 12.6% of cases occurring in familial form. While previous studies have demonstrated differences in disease progression and MRI findings between familial and sporadic MS, there has been no comparison of cognitive impairment between them.
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- Several laboratory markers from a complete blood count (CBC) have been suggested as possible indicators for the risk of cerebral venous thrombosis (CVT), but evidence about this link is limited and conflicting.
- The study involved 295 CVT patients and 341 healthy controls, revealing that CVT patients had higher red cell distribution width (RDW) and lower counts of red blood cells (RBC), hemoglobin (Hb), and hematocrit compared to healthy individuals.
- It was found that female gender, smoking, and higher hematocrit levels were linked to a greater risk of idiopathic CVT (iCVT), suggesting that some CBC parameters could help identify CVT risk and differentiate between types of CVT, highlighting the need
Aims: To evaluate routine blood count parameters as diagnostic and prognostic markers in Multiple Sclerosis (MS) progression.
Patients/methods: 182 patients with Relapsing-Remitting MS (RRMS) and 60 with Secondary Progressive MS (SPMS) were analyzed for blood parameters.
Results: In RRMS, the Expanded Disability Status Scale (EDSS) score correlated positively with Red Cell Distribution Width (RDW).
Patients with multiple sclerosis (MS) face barriers and disparities in accessing care for evaluation and treatment. Given the unmet needs and barriers to access to care, teleservices (e.g.
View Article and Find Full Text PDFBackground: Long non-coding RNAs (lncRNAs) play various roles in gene regulation. GATA3 antisense RNA 1 (GATA3-AS1) is an lncRNA gene neighboring GATA binding protein 3 (GATA3). The current study aims to quantitatively compare the levels of the expression of GATA3-AS1, GATA3, and Interleukin-4 (IL-4) in peripheral blood mononuclear cells (PBMC) samples of MS patients and healthy individuals under the hypothesis of regulation of GATA3 and IL-4 expression orchestrated by GATA3-AS1.
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