Publications by authors named "M Pourcyrous"
Article Synopsis
- This study assessed the effects of in-utero exposure to illicit fentanyl on neonatal outcomes, focusing on conditions like neonatal opioid withdrawal syndrome (NOWS), length of stay (LOS), and treatment needs.
- Conducted from March 2020 to December 2022, the research found that nearly half of the infants in the study had in-utero fentanyl exposure, linked to characteristics such as older maternal age and lower prenatal care.
- Results indicated that fentanyl exposure significantly increased the likelihood and severity of NOWS, necessitated earlier treatment, and was associated with longer hospital stays for both preterm and full-term neonates.
Objective: We sought to determine whether clonidine, a non-opioid α-2-adrenergic agonist, would effectively treat neonatal opioid withdrawal syndrome (NOWS).
Methods: This was an intention-to-treat randomized clinical trial. Enrollment criteria included prenatal opioid exposure, age ≤7 days, gestational age ≥35 weeks, no other medical condition, and need for pharmacotherapy.
Background: Neonatal epileptic seizures cause postictal dysregulation of cerebral blood flow. Hydrogen sulfide (HS), a mediator with vasodilator and antioxidant properties, is produced in the brain by astrocyte cystathionine β-synthase (CBS). This study investigated whether HS improves the cerebral vascular outcome of seizures.
View Article and Find Full Text PDFBackground: Infants born to mothers with opioid use disorder (OUD) and prenatally treated with buprenorphine have a significantly lower incidence of neonatal opioid withdrawal syndrome (NOWS), its treatment duration, and hospital length of stay compared with methadone. However, risk of NOWS remains and clinicians continue to lack an objective methodology to predict NOWS severity among these infants.
Objective: The purpose of this study was to assess the relationship between buprenorphine exposure, umbilical cord tissue (UCT) concentrations, and NOWS development and severity.
Article Synopsis
- A neonate experienced early apnea and bradycardia, requiring chronic ventilator support just 6 hours after birth, without any clear cardiorespiratory or CNS disorders.
- Genetic testing revealed a mutation in the paired-like homeobox 2b gene, confirming the diagnosis of congenital central hypoventilation syndrome (CCHS), a rare genetic disorder affecting respiratory control.
- Unusually, the neonate also exhibited signs of ocular autonomic nervous system dysregulation, detected during the first day of life, including persistent mild dilated pupils that had limited responsiveness to light.