A tool to assist rheumatologists to engage their lupus patients: the Purple Butterfly.

Objective: Translating the highly technical medical jargon of SLE into understandable concepts for patients, their families and individuals without expertise in SLE is a serious challenge. To facilitate communication and enable self-management in SLE, we aimed to create an innovative visual tool, the Purple Butterfly.

Methods: We selected clinically representative criteria for SLE and transposed them as graphical features in an attractive and meaningful visual.

Pharmacological evidence that the inhibitory effects of prostaglandin E2 are mediated by the EP2 and EP4 receptors in human neutrophils.

Prostaglandin E2 (PGE2) is a recognized inhibitor of granulocyte functions. However, most of the data supporting this was obtained when available pharmacological tools mainly targeted the EP2 receptor. Herein, we revisited the inhibitory effect of PGE2 on reactive oxygen species production, leukotriene biosynthesis, and migration in human neutrophils.

The sustainability of trade in wild plants-A data-integration approach tested on critically endangered .

While the demand for many products from wild-harvested plants is growing rapidly, the sustainability of the associated plant trade remains poorly understood and understudied. We integrate ecological and trade data to advance sustainability assessments, using the critically endangered in Nepal to exemplify the approach and illustrate the conservation policy gains. Through spatial distribution modeling and structured interviews with traders, wholesalers, and processors, we upscale district-level trade data to provincial and national levels and compare traded amounts to three sustainable harvest scenarios derived from stock and yield data in published inventories and population ecology studies.

DUOX2 regulates secreted factors in virus-infected respiratory epithelial cells that contribute to neutrophil attraction and activation.

The first line of defense against respiratory viruses relies on the antiviral and proinflammatory cytokine response initiated in infected respiratory epithelial cells. The cytokine response not only restricts virus replication and spreading, but also orchestrates the subsequent immune response. The epithelial Dual Oxidase 2 (DUOX2) has recently emerged as a regulator of the interferon antiviral response.

Leaves Present Anti-Inflammatory Effect.

The ethanol extract (EE) prepared from the leaves of , and its fraction in ethyl acetate (fEA) were evaluated concerning their capacity to reduce inflammation in different experimental models. fEA was also studied concerning its chemical constituents. EE and fEA were assayed for their anti-inflammatory potential, using formalin-induced licking behavior and carrageenan-induced inflammation into the subcutaneous air pouch (SAP) models.