Left ventricular diastolic function and cardiometabolic factors in obese normotensive children.

Background And Aim: Left ventricular (LV) hypertrophy and diastolic function have been found to be associated with obesity and hypertension in adults. However, there are scarce data about the association of obesity itself to cardiac alteration in children. The aim of this study was to detect early changes in LV structure and function in obese children and whether they are associated with the biomarkers of metabolic risk and endothelial activation.

Plasma resistin levels are associated with homocysteine, endothelial activation, and nitrosative stress in obese youths.

Objective: To evaluate whether serum resistin levels are related to cardiovascular risk in obese children.

Design And Methods: Cross-sectional study of 110 children (40 normal weight and 70 severely obese). Clinical and biochemical parameters, including lipid profile, fasting glucose and insulin, and homocysteine, were determined.