Publications by authors named "M Popkova"
Development of DNA Microarray for Parallel Detection of Community-Acquired Pneumonia Bacterial Pathogens.
Sovrem Tekhnologii Med
November 2024
Article Synopsis
- The study aimed to create a DNA microarray for detecting bacterial pathogens causing community-acquired pneumonia in children aged 1-15 years.
- Researchers developed and optimized the microarray design using DNA sequences from the NCBI database and CustomArray technology, focusing on hybridization conditions like DNA amount and temperature.
- The final microarray included 142 probes and was able to effectively identify pneumonia pathogens in clinical samples, achieving reliable sensitivity and specificity in results.
Climate changes influence seasonal tree-ring formation. The result is a specific cell structure dependent on internal processes and external environmental factors. One way to investigate and analyze these relationships is to apply diverse simulation models of tree-ring growth.
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- Animal models are useful for testing new cardiac devices and studying heart rhythm diseases and related heart failure.
- A new small mammal model was developed using New Zealand white rabbits where a pacing lead was successfully implanted in the right ventricular apex for research purposes.
- The study demonstrated stable pacing and potential for chronic use, making it a valuable tool for understanding arrhythmia-induced heart failure.
Article Synopsis
- The study examined the impact of acute cardiac failure (CF) on heart rate variability (HRV) using 24 female pigs subjected to global myocardial hypoxia.
- The results indicated a significant drop in cardiac output and left ventricular ejection fraction, along with an increased heart rate after severe CF was induced.
- Key findings showed a marked reduction in HRV measurements across various analytical methods, highlighting the adverse effects of acute CF on autonomic nervous system function.
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is widely used in the treatment of patients experiencing cardiogenic shock (CS). However, increased VA-ECMO blood flow (EBF) may significantly impair left ventricular (LV) performance. The objective of the present study was to assess the effect of VA-ECMO on LV function in acute CS with concomitant severe aortic stenosis (AS) or mitral regurgitation (MR) in a porcine model.
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