Publications by authors named "M Pontoglio"
Article Synopsis
- * The study reveals that HNF1β remains attached to chromatin during both interphase and mitosis in a specific manner, aided by a protein called BTBD2 that activates Topoisomerase 1 (TOP1) during mitosis.
- * A mutation associated with "maturity onset diabetes of the young" can disrupt the interaction between HNF1β and TOP1, highlighting HNF1β's key role in chromatin remodeling and gene reactivation, which is essential for maintaining cellular identity after cell division.
Background: Bile acids (BAs) act not only as lipids and lipid-soluble vitamin detergents but also function as signaling molecules, participating in diverse physiological processes. The identification of BA receptors in organs beyond the enterohepatic system, such as the farnesoid X receptor (FXR), has initiated inquiries into their organ-specific functions. Among these organs, the kidney prominently expresses FXR.
View Article and Find Full Text PDFShear stress generated by urinary fluid flow is an important regulator of renal function. Its dysregulation is observed in various chronic and acute kidney diseases. Previously, we demonstrated that primary cilium-dependent autophagy allows kidney epithelial cells to adapt their metabolism in response to fluid flow.
View Article and Find Full Text PDFAcute kidney injury is one of the most important complications in patients with COVID-19 and is considered a negative prognostic factor with respect to patient survival. The occurrence of direct infection of the kidney by SARS-CoV-2, and its contribution to the renal deterioration process, remain controversial issues. By studying 32 renal biopsies from patients with COVID-19, we verified that the major pathological feature of COVID-19 is acute tubular injury (ATI).
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