Publications by authors named "M Pomerantz"
Article Synopsis
- The study examines whether "total therapy," which includes various treatments for oligometastatic hormone-sensitive prostate cancer (omHSPC), can result in long-term remission.
- A total of 89 patients were studied, with findings indicating that 45% remained progression-free at three years, suggesting potential long-term remission and possible cure in some cases.
- The research highlights the need for further prospective trials to confirm these outcomes and better understand the effectiveness of total therapy for omHSPC.
Purpose: Deleterious germline variants in certain DNA repair genes are risk factors for developing aggressive prostate cancer. The objective was to quantify their prognostic impact after prostate cancer diagnosis.
Experimental Design: Men with prostate cancer, predominantly of European ancestry, were included from four cohorts with long-term follow-up.
Article Synopsis
- This study analyzed the effects of mindfulness training (MT) on interoceptive awareness in pregnant individuals at risk for hypertension, focusing on how they perceive and manage bodily sensations.
- Twenty-nine participants with prior hypertensive issues were divided into two groups: one received an 8-week MT intervention, while the other continued with standard prenatal care.
- Results showed that those in the MT group reported less anxiety over their physical sensations and improved body awareness, suggesting that MT could help manage pregnancy-related stress and possibly lower blood pressure.
Background: Androgen deprivation therapy (ADT) in prostate cancer (PCa) has been associated with development of insulin resistance. However, the predominant site of insulin resistance remains unclear.
Methods: The ADT & Metabolism Study was a single-center, 24-week, prospective observational study that enrolled ADT-naive men without diabetes who were starting ADT for at least 24 weeks (ADT group, n = 42).
Renal cell carcinoma with sarcomatoid differentiation (sRCC) is associated with poor survival and a heightened response to immune checkpoint inhibitors (ICIs). Two major barriers to improving outcomes for sRCC are the limited understanding of its gene regulatory programs and the low diagnostic yield of tumor biopsies due to spatial heterogeneity. Herein, we characterized the epigenomic landscape of sRCC by profiling 107 epigenomic libraries from tissue and plasma samples from 50 patients with RCC and healthy volunteers.
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