[The significance of isoelectric focusing of unconcentrated cerebrospinal fluid in the detection of oligoclonal zones in multiple sclerosis].

In a group of 31 patients with a confirmed diagnosis of multiple sclerosis the authors assessed the presence of oligoclonal abnormality of gammaglobulins in cerebrospinal fluid. Specimens of non-concentrated cerebrospinal fluid were examined by two separating methods which use as a vehicle polycryamide gel: isoelectric focusing and a modified electrophoretic technique. By isoelectric focusing an oligoclonal state was proved in 71%, the finding was doubtful in 16.