Publications by authors named "M Poglitsch"
Background: Arterial hypertension and left ventricular hypertrophy and remodeling are independent cardiovascular risk factors in patients with Cushing's syndrome. Changes in the renin-angiotensin system and in the mineralocorticoid axis activity could be involved as potential mechanisms in their pathogenesis, in addition to cortisol excess.
Methods: In this ancillary study of our previous study prospectively investigating patients with ACTH-dependent Cushing's syndrome by cardiac magnetic resonance imaging (NCT02202902), 11 patients without any interfering medication were cross-sectionally compared to 20 control subjects matched for age, sex and body mass index.
Background: Autosomal recessive renal tubular dysgenesis is a rare, usually fatal inherited disorder of the renin-angiotensis system (RAS). Herein, we report an adolescent individual experiencing an unknown chronic kidney disease and aim to provide novel insights into disease mechanisms.
Methods: Exome sequencing for a gene panel associated with renal disease was performed.
Background: Angiotensin-(1-12), measured by a self-developed, polyclonal antibody-based radioimmunoassay, has been suggested to act as an alternative precursor of angiotensin II. A more reliable detection method would be liquid chromatography-tandem mass spectrometry.
Methods: We set up the quantification of human and murine angiotensin-(1-12) by liquid chromatography-tandem mass spectrometry and then used this method to measure angiotensin-(1-12) in human, rat, and mouse blood samples, as well as in mouse brain, mouse kidney, and rat heart.
Article Synopsis
- Neutralizing antibodies against SARS-CoV-2, acquired from prior infections or vaccinations, are critical in preventing COVID-19 outbreaks unless the virus changes.
- The study introduces a novel lateral flow assay (LFA) that uses a biomimetic mock virus system with functionalized gold nanoparticles to detect these antibodies in blood samples.
- The assay features enhanced sensitivity for identifying low antibody levels and has been validated against WHO standards, making it reliable for point-of-care testing.