Effect of prostaglandin F2 alpha on the isolated common bile duct of the dog and the rabbit.

In an isolated spiral muscle preparation from the common bile duct of the dog and rabbit contraction was elicited by PGF2 alpha, in a concentration dependent manner. The contraction was long-lasting and reversible. As opposed to PGF2 alpha, morphine, noradrenaline and barium chloride did not induce a contractile response.

Pressure-regulating effects of prostaglandin E2, F2 alpha and cholecystokinin on canine choledochal and pancreatic ducts in vivo.

Changes in pressure in the choledochal and pancreatic ducts of dogs brought about by PGE2 and PGF2 alpha were studied in vivo. The stimulatory action of the c8-terminal cholecystokinin was inhibited by the prostaglandin synthesis inhibitor naproxen. PGF2 alpha increased the pressure, but PGE2 caused a decrease.

[Experimental studies on the relation between cholestasis and pancreatitis].

Animal experiments were carried out on 12 dogs. Dogs are specially qualified because the choledochus and the pancreatic duct seperately fall into the duodenum. Laboratory tests demonstrated the influence of the choledocholigature on the exocrine function of the pancreas.