Publications by authors named "M Pizzuto"
Article Synopsis
- - SARS-CoV-2 has evolved to evade current monoclonal antibodies (mAbs), emphasizing the need for more resilient treatments that can neutralize various viral strains.
- - A new human mAb called VIR-7229 has shown the ability to effectively neutralize multiple variants of SARS-CoV-2 and other related viruses, due to its unique targeting of a critical viral region known as the receptor-binding motif (RBM).
- - VIR-7229 demonstrates a high resistance to the emergence of virus escape mutants, making it a promising candidate for future therapies against evolving coronaviruses.
Gram-negative bacterial lipopolysaccharides (LPSs) trigger inflammatory reactions through Toll-like receptor 4 (TLR4) and prime myeloid cells for inflammasome activation. In phosphate-limited environments, bacteria reduce LPS and other phospholipid production and synthesize phosphorus-free alternatives such as amino-acid-containing lipids like the ornithine lipid (OL). This adaptive strategy conserves phosphate for other essential cellular processes and enhances bacterial survival in host environments.
View Article and Find Full Text PDFThere is limited literature on managing chronic lead exposure from non-removable sources such as lead fragments. In this case report, we present the complexities and clinical considerations involved in treating an elderly patient who sustained a comminuted knee fracture due to a gunshot wound, complicated by retained lead fragments. This case highlights the absence of comprehensive guidelines for managing chronic lead exposure when complete fragment removal is impractical.
View Article and Find Full Text PDFThis is a case of a male child who presented with a progressively enlarging oropharyngeal mass, hyponasal voice, and symptoms of obstructive sleep apnea. Computed tomography imaging of the head and neck revealed a well-circumscribed low-density area of polypoid morphology arising from the left lateral pharyngeal wall, filling most of the posterior oropharynx and extending to a pedicle at the lateral nasopharynx. Histopathological evaluation following surgical excision revealed Antoni A tissue and S100 immunoreactivity.
View Article and Find Full Text PDFArticle Synopsis
- Oleander is a toxic plant with harmful cardiac glycosides that can lead to symptoms mimicking digoxin toxicity, such as gastrointestinal issues and heart problems.
- An 84-year-old man accidentally ingested an oleander leaf infusion, mistaking it for bay laurel, and experienced symptoms, requiring emergency treatment and monitoring.
- The case highlights the need for careful clinical evaluation in oleander poisoning, as standard tests may not effectively measure its cardiac glycosides, and prolonged monitoring is crucial for patient safety.