Publications by authors named "M Pizzo"
Article Synopsis
- This study focused on understanding how common diagnostic uncertainty is when critically ill children are admitted to Pediatric Intensive Care Units (PICUs) and what factors contribute to it.
- Researchers reviewed medical records from 882 pediatric patients across four hospitals to assess the presence of diagnostic uncertainty at admission and how it changed by the time of discharge.
- Key findings indicated that 25.9% of patients showed diagnostic uncertainty upon PICU admission, with significant factors being the time of admission, illness severity, atypical symptoms, and discrepancies in diagnoses between different healthcare providers.
Antisense oligonucleotides (ASOs) are promising therapeutics for treating various neurological disorders. However, ASOs are unable to readily cross the mammalian blood-brain barrier (BBB) and therefore need to be delivered intrathecally to the central nervous system (CNS). Here, we engineered a human transferrin receptor 1 (TfR1) binding molecule, the oligonucleotide transport vehicle (OTV), to transport a tool ASO across the BBB in human TfR knockin (TfR KI) mice and nonhuman primates.
View Article and Find Full Text PDFEndoplasmic reticulum (ER) remodeling is vital for cellular organization. ER-phagy, a selective autophagy targeting ER, plays an important role in maintaining ER morphology and function. The FAM134 protein family, including FAM134A, FAM134B, and FAM134C, mediates ER-phagy.
View Article and Find Full Text PDFThe Eurasian woodcock () belongs to those bird species that make systematic migratory flights in spring and autumn in search of favorable breeding and wintering areas. These specimens arrive in the Mediterranean Area from northeastern European countries during the autumn season. The purpose of this study was to assess whether woodcocks can carry antibiotic resistance genes (ARGs) along their migratory routes.
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