and Concomitant Mutations in a Patient with Metastatic Colon Adenocarcinoma: An Interesting Case Report.

A 68-year-old female patient with tenesmus and blood in the stool was admitted to the S.G. Moscati Hospital of Taranto.

PD-L1 expression in colorectal cancer defines three subsets of tumor immune microenvironments.

Objectives: We investigated the PD-L1 expression in colorectal cancer (CRC) and in its microenvironment.

Results: PD-L1 was expressed in neoplastic cells (NCs) and tumor-infiltrating immune cells (IICs). All samples PD-L1+ on NCs were also on IICs.

Sarcoidosis mimicking metastatic progression of pancreatic neuroendocrine tumor: A case report.

Rationale: Pancreatic neuroendocrine tumors (PNETs) account for less than 5% of all pancreatic tumors. PNETs develop from pancreatic endocrine islet cells and have a variable range of malignant potential. These neoplasms tend to have a slower growth rate than exocrine tumors and may remain undetectable for years.

Are biopsy specimens predictive of HER2 status in gastric cancer patients?

Background: Trastuzumab has been recently proposed as a treatment for patients with HER2-positive advanced/metastatic gastric cancer (GC). Since most patients have inoperable disease at diagnosis, accurate assessment of HER2 status on biopsy specimens is essential to select the patients who may benefit from therapy.

Aim: The aim of this study is to establish whether HER2 status assessed on biopsy material could be reliable for treatment decisions using anti-HER2 agents.