Publications by authors named "M Pilleri"
Article Synopsis
- Parkinson's disease (PD) is a complex disorder influenced by genetic factors, with this study focusing on a cohort from Northeastern Italy to explore its genetic basis and clinical characteristics.
- Using a next-generation sequencing (NGS) panel, researchers identified 133 genetic variants in 218 PD patients, diagnosing monogenic PD in 20% of them, primarily linked to mutations in the GBA1, LRRK2, and PRKN genes.
- The findings suggest that certain clinical criteria, like early age of onset, can reliably predict positive genetic test outcomes, which helps in managing patient care and opens avenues for future therapies targeting specific genetic causes of the disease.
Background: One of the more challenging daily-life actions for Parkinson's disease patients is starting to stand from a sitting position. Parkinson's disease patients are known to have difficulty with self-initiated movements and benefit from external cues. However, the brain processes underlying external cueing as an aid remain unknown.
View Article and Find Full Text PDFBackground: Oral levodopa remains the mainstay of treatment for Parkinson's disease (PD). However, as PD progresses, response to treatment may fluctuate. Managing fluctuations can be demanding for clinicians and patients.
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- Research on how Parkinson's disease affects patients' ability to navigate their environment is limited, primarily due to the constraints of traditional neuroimaging methods that require stillness, leading to reliance on animal models for understanding motor disorders.
- Daily life challenges, such as tripping or falling, are significant issues for Parkinson's patients and a major cause of hospitalization.
- A study using mobile EEG on 14 Parkinson's patients and 17 neurotypical controls found that patients exhibited reduced brain activity in theta and beta frequency bands during obstacle avoidance, indicating difficulties in planning and adapting their movements when facing unexpected challenges.
Background: Deep brain stimulation (DBS) is an established therapeutic option in advanced Parkinson's disease (PD). Literature data and recent guidelines remain inconclusive about the best choice as a target between the subthalamic nucleus (STN) and the globus pallidus internus (GPi).
Materials And Methods: We retrospectively reviewed the clinical efficacy outcomes of 48 DBS-implanted patients (33 STN-DBS and 15 GPi-DBS) at a short- (<1 year from the surgery) and long-term (2-5 years) follow-up.