Publications by authors named "M Pillai"
Purpose: To assess the safety and efficacy of non-penetrating deep sclerectomy (NPDS) in advanced open-angle glaucoma patients.
Design: Retrospective observational study.
Methods: Forty-two eyes of 38 patients with advanced glaucoma who underwent NPDS surgery combined with mitomycin-C with or without phacoemulsification were evaluated for up to 12 months at a tertiary eye care center in South India.
Objective: To assess the accuracy of a large language model (LLM) in measuring clinician adherence to practice guidelines for monitoring side effects after prescribing medications for children with attention-deficit/hyperactivity disorder (ADHD).
Methods: Retrospective population-based cohort study of electronic health records. Cohort included children aged 6 to 11 years with ADHD diagnosis and 2 or more ADHD medication encounters (stimulants or nonstimulants prescribed) between 2015 and 2022 in a community-based primary health care network (n = 1201).
Article Synopsis
- Bloodborne pathogens (BBPs) are a serious global health threat affecting both humans and animals, with notable risks for healthcare workers who face potential exposure.
- The paper critiques traditional detection methods like PCR and ELISA, pushing for new detection technologies enhanced by advances in sensor tech.
- It aims to educate on bloodborne infections, detailing their transmission patterns and emphasizing the need for improved management and detection strategies.
Article Synopsis
- TDP-43 aggregation is linked to neurodegenerative diseases like ALS, with specific mutations (D169G and P112H) affecting its stability and aggregation.
- The P112H mutant exhibits higher chemical stability at physiological pH but forms amyloid fibrils more rapidly at low pH compared to TDP-43 and D169G.
- This study combines experimental and simulation techniques to reveal how the mutations influence the conformational changes and aggregation process of TDP-43, highlighting the role of ionic strength and charge in the aggregation behavior.
Psoriasis is a chronic T-cell-mediated autoimmune skin disorder characterized by excessive epidermal thickening, overproliferation of keratinocyte, disruption of epidermal cell differentiation, and increased blood vessel growth in the dermal layer. Despite the common use of corticosteroids in psoriasis treatment, their limited efficacy and numerous side effects pose significant challenges. This research introduces a promising alternative approach by encapsulating eugenol (EU) in soya phosphatidylcholine (SPC) nanoparticles (EUNPs) which showed spherical shape nanoparticles with a hydrodynamic size of approximately 200 nm, polydispersity index 0.
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