Long-term outcome and risk stratification in compensated advanced chronic liver disease after HCV-cure.

Background And Aims: Around 750,000 patients per year will be cured of HCV infection until 2030. Those with compensated advanced chronic liver disease remain at risk for hepatic decompensation and de novo HCC. Algorithms have been developed to stratify risk early after cure; however, data on long-term outcomes and the prognostic utility of these risk stratification algorithms at later time points are lacking.

Prevalence and Characterization of Staphylococcus aureus Isolated from Meat and Milk in Northeastern Italy.

Staphylococcus aureus is a pathogenic microorganism often found in animal-derived foods and is known for its ability to readily develop resistance to antibiotic treatments. This study was designed to determine the prevalence of S. aureus strains in raw milk and meat in Italy and to evaluate their antibiotic resistance profiles and biofilm production.

Regenerative medicine: Hydrogels and mesoporous silica nanoparticles.

Hydrogels, that are crosslinked polymer networks, can absorb huge quantities of water and/or biological fluids. Their physical properties, such as elasticity and soft tissue, together with their biocompatibility and biodegradability, closely resemble living tissues. The versatility of hydrogels has fuelled their application in various fields, such as agriculture, biomaterials, the food industry, drug delivery, tissue engineering, and regenerative medicine.

Leaching profile of per- and polyfluoroalkyl substances (PFAS) from biosolids after thickening, anaerobic digestion, and dewatering processes, and significance of protein, phosphorus, and selected ions.

Batch leaching experiments were conducted to evaluate the release of forty per- and polyfluoroalkyl substances (PFAS) from sludge samples collected after thickening, anaerobic digestion, and dewatering processes at two wastewater treatment plants. The South District wastewater treatment plant (SDWWTP), which receives domestic wastewater and landfill leachate from a nearby landfill, and the Central District wastewater treatment plant (CDWWTP), which receives only domestic wastewater, were selected for this study. PFAS released into the aqueous phase were analyzed by sacrificial sampling after 1, 3, 7, 14, and 30 days.

Supplementation with a Whey Protein Concentrate Enriched in Bovine Milk Exosomes Improves Longitudinal Growth and Supports Bone Health During Catch-Up Growth in Rats.

Background: Undernutrition impairs linear growth while restoration of nutritional provisions leads to accelerated growth patterns. However, the composition of the nutrition provided is key to facilitating effective catch-up growth without compromising bone quantity, quality, and long-term health.

Methods: We evaluated the role of a whey protein concentrate enriched in bovine milk exosomes (BMEs) in modulating the proliferative properties of human chondrocytes in vitro and studied how these effects might impact bone quantity and quality measured as longitudinal tibia growth, bone mineral content (BMC) and density (BMD), and trabecular micro-CT parameters in stunted rats during catch-up growth.