Publications by authors named "M Pigeyre"
Background: The relationship between ankle blood pressure (BP) and cardiovascular disease remains unclear. We examined the relationships between known and new ankle BP indices and major cardiovascular outcomes in people with and without type 2 diabetes.
Methods: We used data from 3 large trials with measurements of ankle systolic BP (SBP), ankle-brachial index (ABI, ankle SBP divided by arm SBP), and ankle-pulse pressure difference (APPD, ankle SBP minus arm pulse pressure).
Article Synopsis
- - The study explored how and why overweight and obese pregnant women participated in an educational program that included nutritional workshops and physical activity sessions, with the goal of improving health behaviors and outcomes.
- - Of the 187 women invited, only about 61.5% participated, and even fewer (45%) regularly attended sessions; higher household income correlated with regular attendance.
- - While participation did not significantly change overall eating behaviors or physical activity levels, women who regularly attended showed temporary improvements in positive emotional well-being during the program.
Background: Epigenetic modifications, particularly DNA methylation (DNAm) in cord blood, are an important biological marker of how external exposures during gestation can influence the in-utero environment and subsequent offspring development. Despite the recognized importance of DNAm during gestation, comparative studies to determine the consistency of these epigenetic signals across different ethnic groups are largely absent. To address this gap, we first performed epigenome-wide association studies (EWAS) of gestational age (GA) using newborn cord blood DNAm comparatively in a white European (n = 342) and a South Asian (n = 490) birth cohort living in Canada.
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- Cognitive decline is a major concern with aging, linked to higher risks of dementia and stroke, though the exact causes are unclear.
- A study of 1160 proteins in plasma found five that are associated with cognitive function, specifically in a test called DSST, with two proteins (NCAN and CDCP1) showing consistent results in a follow-up group.
- The research indicates that some proteins may influence brain health and stroke risk, suggesting avenues for future research and potential drug treatments to help mitigate cognitive decline and related risks.
Article Synopsis
- The study aimed to find clinical and biochemical indicators that can point out individuals with dysglycaemia (diabetes/pre-diabetes) who do not experience serious health issues during follow-up.
- Researchers analyzed data from the ORIGIN study involving over 12,500 adults to determine factors linked to remaining free from major health outcomes over a median follow-up of 6.2 years.
- Key findings showed that younger age, female sex, and specific clinical and biomarker profiles can effectively identify individuals with prediabetes or early type 2 diabetes who are least likely to face serious health complications.