Physics-Based Synthetic Data Model for Automated Segmentation in Catalysis Microscopy.

In catalysis research, the amount of microscopy data acquired when imaging dynamic processes is often too much for nonautomated quantitative analysis. Developing machine learned segmentation models is challenged by the requirement of high-quality annotated training data. We thus substitute expert-annotated data with a physics-based sequential synthetic data model.

Structure-Activity Relationship Studies of Tetracyclic Pyrrolocarbazoles Inhibiting Heterotetrameric Protein Kinase CK2.

The serine/threonine kinase CK2 (formerly known as casein kinase II) plays a crucial role in various CNS disorders and is highly expressed in various types of cancer. Therefore, inhibiting this key kinase could be promising for the treatment of these diseases. The CK2 holoenzyme is formed by the recruitment of two catalytically active CK2α and/or CK2α' subunits by a regulatory CK2β dimer.

Effort-reward imbalance and burnout among German school leaders. Representative study findings and implications for an underserved occupational group.

This study examines the relationship between gratification crisis and burnout syndrome in German school leaders and explores how sociodemographic and school-level factors relate to burnout. Additionally, it investigates how these factors influence the likelihood of experiencing burnout and engagement based on sociodemographic and school characteristics. The research design focuses on the relationship between the effort-reward imbalance (ERI) model and latent profiles of the Maslach Burnout Inventory.

Multinational investigation of a Umbilo outbreak reveals rocket salad and baby spinach as the likely infection vehicles, Europe, 2024.

A food-borne outbreak with about 200 Umbilo cases occurred mainly between July and September 2024 in several European countries. Collaborative work between outbreak teams in Germany, Austria and Denmark, including epidemiological and microbiological investigations, allowed to rapidly identify rocket salad as the likely infection vehicle. Umbilo was detected in rocket salad, and later in baby spinach.